Alzheimer and Schizophrenia
Study design regulating postsynaptic expression of AMPA receptors. AMPA receptors (AMPAR) are stabilized at the PSD by GRIP1 proteins. Binding…
Niemann-Pick-C desease
The Niemann-Pick-C disease (NPC) is a rare disease affecting 1 child in 100,000. The NPC normally manifest itself early in…
CRASH Syndrome
Whereas remarkable advances have been made in understanding brain development, the mechanisms that protect the nervous system architecture throughout life…
Rett-atypic syndrome and congenital mirror movement disorder
The mechanisms involved in brain development, including the guidance of migrating neurons, have been extensively studied over the past two…
Amyloidosis
Study of the kinetics of amyloid fiber formation by thioflavin-T and transmission electron microscopy
Congenital Mirror Movements
Congenital Mirror Movements (CMM) is a rare neurodevelopmental disorder, characterized by voluntary movements from one side of the body that…
Orphan neurodevelopmental deseases (research program)
Our research program has two interrelated axes aimed at understanding the cellular and molecular mechanisms of (1) nervous system development,…
CHARGE Syndrome
Mutations in the ATP-dependent chromatin remodeller chromodomain, helicase, DNA binding (CHD) 7 are the primary cause of CHARGE syndrome and…
Neurodegenerative diseases and Fanconi anemia (research program)
My research program concerns the structure-function study of post-translational modifications of proteins and, more specifically, the study of SUMOylation of…