- Cet évènement est passé
Pause-conférence | Pr Daniel Bernard (McGill)
4 février 2020 @ 12:00 - 13:00 EST
Crédit : hormone.org
De nouvelles perspectives sur le contrôle neuroendocrinien de la reproduction
Le Pr Daniel Bernard, professeur à l’Université de McGill, sera l’invité du Pr Nicolas Pilon, membre régulier du CERMO-FC, le Mardi 4 févirer à 12h00 au PK-1140.
En savoir plus sur les recherches du Pr Bernard.
Novel insights into the neuroendocrine control of reproduction
Pr Daniel Bernard, a professor at McGill University, will be the guest of Pr Nicolas Pilon, a regular member of CERMO-FC, on Tuesday, February 4th at 12:00 in PK-1140.
Learn more about Professor Bernard research.
Summary: Successful reproduction depends on hormones from the brain, pituitary gland, and gonads. The hypothalamic decapeptide, gonadotropin-releasing hormone (GnRH), represents the final common pathway through which the brain controls fertility. GnRH binds to the GnRH receptor (GnRHR), a G protein coupled receptor, on the surface of pituitary gonadotrope cells to regulate the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH, collectively known as the gonadotropins, regulate key aspects of gonadal function include germ cell development and sex steroid production. GnRH is released in pulses and pulse frequency differentially regulates the secretion of LH and FSH. How gonadotrope cells decode pulse frequency is a long-standing and unanswered question. One hypothesis is that the GnRHR couples to different G proteins at different GnRH pulse frequencies. We tested this idea by ablating Gs or Gq/11 in murine gonadotropes. A second unanswered question in the field is the adaptive significance of a specialization in the mammalian GnRHR. Unlike the GnRHR in other vertebrates, mammalian GnRHRs lack an intracellular C-terminal tail (C-tail). In mammals, a high amplitude, long duration release of LH (the LH surge) drives ovulation. It has been argued that the loss of the GnRHR C-tail enables the LH surge. We tested this idea by generating mice with a knockin mutation that adds a C-tail to the GnRHR. In this lecture, I will discuss the results of these mouse models and how they challenge our current conceptions of GnRH action and the central control of reproduction.
Biography : Ph.D. from Johns Hopkins University (1995), with Greg Ball. Post-doctoral at Northwestern University, with Teresa Woodruff. First independent position: Staff Scientist (Assistant Professor equivalent) at the Population Council’s Center for Biomedical Research at The Rockefeller University in New York City (2001-2006). Second and current position: Department of Pharmacology and Therapeutics at McGill University (Associate Professor from 2006-2014; Professor from 2014-Present). Additional appointments: Department of Anatomy and Cell Biology, Department of Physiology, Division of Endocrinology and Metabolism, Integrated Program in Neuroscience at McGill. Former Director of the McGill Centre for Research in Reproduction and Development. Current Director of Réseau Québécois en Reproduction. Former member of the Board of Directors of the Endocrine Society (2016-2019). Current member of the Board of Directors of the Society for the Study of Reproduction (2019-present). Former Section 1 Director of the Frontiers in Reproduction course at the Marine Biology Lab in Woods Hole, Massachusetts (2015-2019). Service on many peer review panels at CIHR and NIH. Currently an Associate Editor at Endocrinology. Funded by the Lalor Foundation, NIH, CIHR, NSERC, FRQNT, and FRQS (salary). Currently by CIHR and NSERC. 112 career publications (including reviews).
Un évènement organisé dans le cadre des Pause-conférences du CERMO-FC et soutenu par :
An event organized as part of the Pause-conférences of CERMO-FC, and support by :
